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Importantly, hypervirulent clinical M. We show that unitarily equivalent Hamiltonians on the grid generate reaction matrices which are compatible with Levinson's theorem but are phase-inequivalent along the SRG trajectory. While the Wilson generator induces an ascending ordering incompatible with Levinson's theorem, the Wegner generator provides a much better ordering, although not the optimal one. We show how the SRG with different generators G induces different isospectral flows in the presence of bound-states, leading to distinct orderings in the infrared limit. Ates, Louis S. This indicates that these ESX-5 substrates have an important role in virulence attenuation.

Ates, Louis S. Most of these proteins are transported by the different type VII secretion systems1,2.

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The most recently evolved type VII secretion system, ESX-5, secretes dozens of substrates belonging to the PE and PPE families, which are named for conserved proline and glutamic acid residues close to the amino terminus3,4.

However, the role of these proteins remains largely elusive1.

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Importantly, hypervirulent clinical M. Restoration of PPEdependent secretion partially reverted the hypervirulence phenotype of a Beijing strain, and deletion of ppe38 in moderately virulent M. This indicates that these ESX-5 substrates have an important role in virulence attenuation.

Most of these proteins are transported by the different type VII secretion systems 1,2. The most recently evolved type VII secretion system, ESX-5, secretes dozens of substrates Slimming B to the PE and PPE families, which are named for conserved proline and glutamic acid residues close to the amino terminus 3,4.

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However, the role of these proteins remains largely elusive 1. Phylogenetic analysis revealed that deletion of ppe38 occurred at the branching point of the 'modern' Beijing sublineage and is shared by Beijing outbreak strains worldwide, suggesting that this deletion may have contributed to their success and global distribution 6,7.

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